Melanotan II was first synthesized at the University of Arizona. Researchers there knew that one of the best defenses against skin cancer was melanin activated in the skin, a tan. They hypothesized that an effective way to reduce skin cancer rates in people would be to induce the body's natural pigmentary system to produce a protective tan prior to UV exposure. The body's naturally occurring hormone α-MSH causes melanogenesis, a process by which the skin's pigment cells (melanocytes) produce the skin's pigment (melanin). They tested to see if administering this endogenous hormone to the body directly could be an effective method to cause sunless tanning. What they found was that while it appeared to work, natural α-MSH had too short a half life in the body to be practical as a therapeutic drug. So they decided to find a more potent and stable alternative, one that would be more practical and so Melanotan 2 was born.
There are a few side effects which users of Melanotan 2 should be aware of. Most clinical trials have shown darkening of the moles and freckles and not particularly visible moles will become noticeable in the loading phase of MT2, after 10-15 days of use your skin darkens around and an even tan is then acquired. Mild nausea has also been reported which could result in weight loss from loss of appetite. In men, Melanotan 2 has also proven to be a potent libido boost and enhances erectile functionality.